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2006 1
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146 results

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Page 1
N6-Methyladenosine Modification Controls Circular RNA Immunity.
Chen YG, Chen R, Ahmad S, Verma R, Kasturi SP, Amaya L, Broughton JP, Kim J, Cadena C, Pulendran B, Hur S, Chang HY. Chen YG, et al. Mol Cell. 2019 Oct 3;76(1):96-109.e9. doi: 10.1016/j.molcel.2019.07.016. Epub 2019 Aug 29. Mol Cell. 2019. PMID: 31474572 Free PMC article.
Mammalian cells possess innate immunity to detect foreign circRNAs, but the molecular basis of self versus foreign identity in circRNA immunity is unknown. Here, we show that N6-methyladenosine (m(6)A) RNA modification on human circRNAs inhibits innate immunity. Foreign ci …
Mammalian cells possess innate immunity to detect foreign circRNAs, but the molecular basis of self versus foreign identity in circRNA immun …
circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity.
Li B, Zhu L, Lu C, Wang C, Wang H, Jin H, Ma X, Cheng Z, Yu C, Wang S, Zuo Q, Zhou Y, Wang J, Yang C, Lv Y, Jiang L, Qin W. Li B, et al. Nat Commun. 2021 Jan 12;12(1):295. doi: 10.1038/s41467-020-20527-z. Nat Commun. 2021. PMID: 33436560 Free PMC article.
This TRIM25/circNDUFB2/IGF2BPs ternary complex facilitates ubiquitination and degradation of IGF2BPs, with this effect enhanced by N(6)-methyladenosine (m(6)A) modification of circNDUFB2. Moreover, circNDUFB2 is also recognized by RIG-I to activate RIG-I-MAVS signaling cas …
This TRIM25/circNDUFB2/IGF2BPs ternary complex facilitates ubiquitination and degradation of IGF2BPs, with this effect enhanced by N(6)-meth …
5-methylcytosine (m(5)C) RNA modification controls the innate immune response to virus infection by regulating type I interferons.
Zhang Y, Zhang LS, Dai Q, Chen P, Lu M, Kairis EL, Murugaiah V, Xu J, Shukla RK, Liang X, Zou Z, Cormet-Boyaka E, Qiu J, Peeples ME, Sharma A, He C, Li J. Zhang Y, et al. Proc Natl Acad Sci U S A. 2022 Oct 18;119(42):e2123338119. doi: 10.1073/pnas.2123338119. Epub 2022 Oct 14. Proc Natl Acad Sci U S A. 2022. PMID: 36240321 Free PMC article.
However, the potential role of RNA m(5)C methylation in innate immunity remains elusive. Here, we show that depletion of NSUN2, an m(5)C methyltransferase, significantly inhibits the replication and gene expression of a wide range of RNA and DNA viruses. ...However, …
However, the potential role of RNA m(5)C methylation in innate immunity remains elusive. Here, we show that depletion of NSUN2, an …
Rhinovirus-induced epithelial RIG-I inflammasome suppresses antiviral immunity and promotes inflammation in asthma and COVID-19.
Radzikowska U, Eljaszewicz A, Tan G, Stocker N, Heider A, Westermann P, Steiner S, Dreher A, Wawrzyniak P, Rückert B, Rodriguez-Coira J, Zhakparov D, Huang M, Jakiela B, Sanak M, Moniuszko M, O'Mahony L, Jutel M, Kebadze T, Jackson DJ, Edwards MR, Thiel V, Johnston SL, Akdis CA, Sokolowska M. Radzikowska U, et al. Nat Commun. 2023 Apr 22;14(1):2329. doi: 10.1038/s41467-023-37470-4. Nat Commun. 2023. PMID: 37087523 Free PMC article.
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Mehrbod P, Ande SR, Alizadeh J, Rahimizadeh S, Shariati A, Malek H, Hashemi M, Glover KKM, Sher AA, Coombs KM, Ghavami S. Mehrbod P, et al. Virulence. 2019 Dec;10(1):376-413. doi: 10.1080/21505594.2019.1605803. Virulence. 2019. PMID: 30966844 Free PMC article. Review.
Abbreviation: AIDS: Acquired Immunodeficiency Syndrome; ATF6: Activating Transcription Factor 6; ATG6: Autophagy-specific Gene 6; BAG3: BCL Associated Athanogene 3; Bak: BCL-2-Anatagonist/Killer1; Bax; BCL-2: Associated X protein; Bcl-2: B cell Lymphoma 2x; BiP: Chaperon immunogl …
Abbreviation: AIDS: Acquired Immunodeficiency Syndrome; ATF6: Activating Transcription Factor 6; ATG6: Autophagy-specific Gene 6; BAG3: BCL …
Senecavirus A-induced glycolysis facilitates virus replication by promoting lactate production that attenuates the interaction between MAVS and RIG-I.
Li H, Lin C, Qi W, Sun Z, Xie Z, Jia W, Ning Z. Li H, et al. PLoS Pathog. 2023 May 1;19(5):e1011371. doi: 10.1371/journal.ppat.1011371. eCollection 2023 May. PLoS Pathog. 2023. PMID: 37126525 Free PMC article.
SVA induces glycolysis in PK-15 cells, as indicated by significantly increased expression of hexokinase 2 (HK2), 6-phosphofructokinase (PFKM), pyruvate kinase M (PKM), phosphoglycerate kinase 1 (PGK1), hypoxia-inducible factor-1 alpha (HIF-1alpha), and superoxide dismutase …
SVA induces glycolysis in PK-15 cells, as indicated by significantly increased expression of hexokinase 2 (HK2), 6-phosphofructokinase (PFKM …
Epigenetic addition of m(5)C to HBV transcripts promotes viral replication and evasion of innate antiviral responses.
Ding S, Liu H, Liu L, Ma L, Chen Z, Zhu M, Liu L, Zhang X, Hao H, Zuo L, Yang J, Wu X, Zhou P, Huang F, Zhu F, Guan W. Ding S, et al. Cell Death Dis. 2024 Jan 12;15(1):39. doi: 10.1038/s41419-023-06412-9. Cell Death Dis. 2024. PMID: 38216565 Free PMC article.
Eukaryotic five-methylcytosine (m(5)C) is an important regulator of viral RNA splicing, stability, and translation. ...Hence, the delicate regulation of NSUN2 expression induces m(5)C modification of HBV mRNA while decreasing the levels of m(5)C in host IFN m …
Eukaryotic five-methylcytosine (m(5)C) is an important regulator of viral RNA splicing, stability, and translation. ...Hence, the del …
146 results