5-methylcytosine (m(5)C) RNA modification controls the innate immune response to virus infection by regulating type I interferons.
Zhang Y, Zhang LS, Dai Q, Chen P, Lu M, Kairis EL, Murugaiah V, Xu J, Shukla RK, Liang X, Zou Z, Cormet-Boyaka E, Qiu J, Peeples ME, Sharma A, He C, Li J.
Zhang Y, et al.
Proc Natl Acad Sci U S A. 2022 Oct 18;119(42):e2123338119. doi: 10.1073/pnas.2123338119. Epub 2022 Oct 14.
Proc Natl Acad Sci U S A. 2022.
PMID: 36240321
Free PMC article.
However, the potential role of RNA m(5)C methylation in innate immunity remains elusive. Here, we show that depletion of NSUN2, an m(5)C methyltransferase, significantly inhibits the replication and gene expression of a wide range of RNA and DNA viruses. ...However, …
However, the potential role of RNA m(5)C methylation in innate immunity remains elusive. Here, we show that depletion of NSUN2, an …